This examination was gone for exploring lycopene action on cyclooxygenase and lipid peroxidation in dexamethasone-treated Wistar rodents. Twenty (20) male Wistar rodents weighing between 150g-250g were haphazardly chosen into four gatherings containing five rodents each. Control rodents got standard feed and water. Gathering two got 3mg/kg body weight of dexamethasone intraperitoneally every two days for 9 days. Gathering 3 got 3mg/kg body weight of dexamethasone intraperitoneally every two days for 9 days in addition to day by day oral organization of 1mg/kg of lycopene for 28 days. Results demonstrated that there was no critical distinction in the action of dexamethasone and lycopene on COX and THX-A 2 in every one of the gatherings. Dexamethasone expanded AST ALT and ALT levels. Treatment with Lycopene fundamentally (p<0.01) diminished AST, ALT, and ALP in every one of the gatherings. Lactate dehydrogenase movement was fundamentally (p<0.01) diminished in the dexamethasone and further brought down upon treatment with lycopene when contrasted with the DEX gathering. Malondialdehyde (MDA) fixation in Dex was expanded (p<0.01), Catalase action was diminished while SOD focus was not modified. Treatment with lycopene Significantly (p<0.01) diminished serum MDA and expanded catalase fixation.